Nitric Oxide Influences HSV-1-Induced Neuroinflammation
نویسندگان
چکیده
منابع مشابه
Kinetics of Nitric Oxide Production and MTT Reduction by HSV-1 Infected Macrophages
Background: Macrophages have important role in defense against Herpes Simplex Virus type-1 (HSV-1). The present study was performed to determine the viability and nitric oxide (NO) production by HSV-1 infected mouse peritoneal macrophages (HIM). Method: The viability of macrophages was evaluated using MTT reduction assay and the production of nitrite using Griess method. Results: The ability of...
متن کاملkinetics of nitric oxide production and mtt reduction by hsv-1 infected macrophages
background: macrophages have important role in defense against herpes simplex virus type-1 (hsv-1). the present study was performed to determine the viability and nitric oxide (no) production by hsv-1 infected mouse peritoneal macrophages (him). method: the viability of macrophages was evaluated using mtt reduction assay and the production of nitrite using griess method. results: the abilit...
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Nitric oxide (NO) generated by inducible NO synthase (iNOS) is critical for defense against intracellular pathogens but may mediate inflammatory tissue damage. To elucidate the role of iNOS in neuroinflammation, infections with encephalitogenic Trypanosoma brucei parasites were compared in inos(-/-) and wild-type mice. Inos(-/-) mice showed enhanced brain invasion by parasites and T cells, and ...
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Ryanodine receptors (RyRs), located in the sarcoplasmic/endoplasmic reticulum (SR/ER) membrane, are required for intracellular Ca2+ release that is involved in a wide range of cellular functions. In addition to Ca2+-induced Ca2+ release in cardiac cells and voltage-induced Ca2+ release in skeletal muscle cells, we recently identified another mode of intracellular Ca2+ mobilization mediated by R...
متن کاملRole of nitric oxide in the onset of facial nerve palsy by HSV-1 infection.
IMPORTANCE Although herpes simplex virus type 1 (HSV-1) is a causative agent of Bell palsy, the precise mechanism of the paralysis remains unknown. It is necessary to investigate the pathogenesis and treatment of Bell palsy due to HSV-1 infection. OBJECTIVE This study elucidated the role of nitric oxide (NO) in the incidence of facial nerve paralysis caused by HSV-1 in mice and to evaluate th...
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ژورنال
عنوان ژورنال: Oxidative Medicine and Cellular Longevity
سال: 2019
ISSN: 1942-0900,1942-0994
DOI: 10.1155/2019/2302835